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Long-term drinking upregulates cytochrome P450 2E1 (CYP2E1), which leads to an increased acetaldehyde concentration and decreased activity of aldehyde dehydrogenase, thus reducing the oxidation of acetaldehyde, resulting in the accumulation of acetaldehyde, eventually causing direct damage to hepatocytes (Meroni et al., 2018)

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177 WangB.JieZ.JooD.OrdureauA.LiuP.GanW.et al (2017)

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